Consult a health care practitioner if:
- you have a history of disease related to female hormone such as ovarian cancer, uterine fibroids, or endometriosis
- you experience symptoms such as breast pain, soreness, tenderness, or uterine bleeding after starting red clover
- you are taking hormone replacement therapy
In addition, anytime when the symptoms worsen, you should consult a health care practitioner.
Currently, the evidence is conflicting for the effect of red clover on menopausal and postmenopausal symptoms. There is not enough scientific evidence to determine whether red clover is effective for any other health conditions.
Red clover seems to be safe for most adults when used for short periods of time. No serious adverse effects have been reported. Common side effects include muscle pain, nausea, and vaginal spotting.
Because red clover contains estrogen-like compounds, there is a possibility that its long-term use may increase the risk of people developing cancer of the lining of the uterus. Be sure to complete clinical testing such as any mammograms or ultrasound scans of the lining of the uterus before taking red clover.
Red clover may interact with:
- medications that use estrogen receptors such as oral contraceptive drugs and estrogen replacement therapy.
- methotrexate
- tamoxifen
It is unclear whether red clover is safe for people who are pregnant or breast-feeding, or who have breast cancer or other hormone-sensitive cancers.
Before taking any new medications, including natural health products, speak to your physician, pharmacist, or other health care provider. Tell your health care provider about any natural health products you may be taking.