Medication Search​ - Flolan

Explore the medications listed in our database.


Common Name:



How does Flolan work? What will it do for me?

Epoprostenol belongs to the class of medications called vasodilators. Vasodilators open up (dilate) the blood vessels in your body by relaxing the muscle walls of the blood vessels. This helps to lower blood pressure and allow blood to flow more easily throughout your body, which improves your heart function and your ability to exercise.

Epoprostenol is used to for the long-term treatment of pulmonary hypertension. People with pulmonary hypertension have high blood pressure in the blood vessels of the lungs. The high pressure makes it difficult for blood to travel to the lungs and pick up oxygen. This makes the heart work harder in order to push enough blood into the lungs, which over time can lead to heart problems.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given this medication, speak to your doctor. Do not stop using this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use this medication if their doctor has not prescribed it.

What form(s) does Flolan come in?

Each vial of sterile, freeze-dried powder contains epoprostenol sodium equivalent to epoprostenol 0.5 mg (500,000 ng) or 1.5 mg (1,500,000 ng). Nonmedicinal ingredients: glycine, mannitol, sodium chloride, and sodium hydroxide (added to adjust pH). Each vial of sterile diluent contains glycine 94 mg, sodium chloride 73.3 mg, sodium hydroxide (added to adjust pH), and water for injection.

How should I use Flolan?

The dose of epoprostenol is based on body weight. The recommended starting dose is 2 mg per kilogram of bodyweight, per hour. Your doctor will monitor your response to the medication and may adjust the dose based on how you respond.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

Epoprostenol is injected intravenously (into a vein) by a procedure called continuous intravenous infusion. This means that the medication will be flowing into your body on a constant basis. You will need to have a special device inserted into your vein for the medication to be given (called a central venous catheter).

Sometimes, this medication will be given in the hospital by a health care professional. At other times, it may be given to you while you are at home or outside the hospital. In this situation, you will have a special pump that will help deliver the medication into your vein. A health care professional will teach you (and your caregiver or family member) how to prepare the medication and how to use the pump. Only use the tubing supplied to you with your medication or by your health care professional.

It is important this medication be used exactly as recommended by your doctor. If your infusion of epoprostenol is interrupted for any reason, contact your doctor to discuss what you should do.

Store the unmixed vials of medication and diluents at room temperature (between 15°C to 25°C), protect it from light, and keep out of the reach of children. Do not freeze.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take Flolan?

Do not use epoprostenol if you:

  • are allergic to epoprostenol, or any ingredients of the medication
  • are allergic to any medications with a similar chemical structure to epoprostenol
  • develop pulmonary edema (fluid in the lungs) when starting the medication
  • have congestive heart failure

What side effects are possible with Flolan?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • back pain
  • diarrhea
  • dizziness
  • dry mouth
  • flushing
  • headache
  • heartburn
  • increased sensitivity to touch
  • increased sweating
  • jaw discomfort
  • lightheadedness
  • loss of appetite
  • nausea
  • pain, redness, or rash at the site of infusion
  • restlessness
  • tingling or numbness of the hands or feet
  • tiredness
  • trouble sleeping
  • vomiting
  • weakness

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • abdominal pain
  • agitation
  • anxiety
  • bone and joint pain
  • change in heart rate (fast or slow)
  • difficulty breathing
  • muscle pain
  • nervousness
  • signs of bleeding (e.g., bloody, black, or tarry stools; nosebleeds; blood in urine; coughing blood; bleeding gums; cuts that don’t stop bleeding; vomiting blood or material that looks like coffee grounds)
  • signs of intravenous line blockage (e.g., dizziness, weakness, shortness of breath)
  • symptoms of an intravenous line infection (e.g., redness, tenderness, swelling, or pus at the infusion site)
  • symptoms of low blood pressure (e.g., fainting, severe dizziness)
  • symptoms of too much blood pumping from the heart (e.g., persistent cough, shortness of breath, fatigue, swelling of the legs and abdomen)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • chest pain
  • signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
  • sudden onset of fever
  • symptoms of a blood infection (e.g., fever, headache, fatigue)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for Flolan?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Bleeding: Epoprostenol prevents platelets in the blood from sticking together, which can put you at risk for bleeding. If you experience any signs or symptoms of bleeding (e.g., black and tarry stools, blood in the urine, easy bruising, cuts that won’t stop bleeding), contact your doctor immediately. While you are taking this medication, your doctor should closely monitor your platelet counts with blood tests.

Drowsiness/reduced alertness: This medication may cause drowsiness or dizziness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how this medication affects you.

Infection: Since this medication is given intravenously through a central venous catheter, this increases your risk of infections in the blood, which can be fatal. If you notice any signs or symptoms such as a sudden onset of fever, fatigue, or headache, contact your doctor immediately.

Giving the medication intravenously also puts you at increased risk of infections at the infusion site. Contact your doctor as soon as possible if you notice symptoms such as redness, tenderness, swelling, or pus at the infusion site.

Low blood pressure (hypotension): Epoprostenol works to reduce the pressure in the blood vessels by dilating the blood vessels. People being treated with epoprostenol should avoid situations that can further dilate their blood vessels, such as sitting in saunas, hot baths, and sunbathing.

Stopping the medication: When epoprostenol is stopped suddenly, or the dose is decreased by a large amount, symptoms of pulmonary hypertension may occur. If your epoprostenol infusion is stopped abruptly for some reason and you develop symptoms such as pain when breathing (dyspnea), dizziness, weakness, and fatigue, contact your doctor immediately.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if epoprostenol passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

Seniors: The safety of using this medication has not been established for seniors. Seniors may be at greater risk for side effects such as kidney, liver, or heart problems and should be monitored closed.

What other drugs could interact with Flolan?

There may be an interaction between epoprostenol and any of the following:

  • acetylsalicylic acid
  • aldesleukin
  • aliskiren
  • alpha-blockers (e.g., alfuzosin, doxazosin, tamsulosin)
  • alpha-agonists (e.g., clonidine, methyldopa)
  • amifostine
  • amiodarone
  • angiotensin converting enzyme (ACE) inhibitors (e.g., captopril, enalapril, ramipril)
  • angiotensin II receptor blockers (e.g., irbesartan, losartan, valsartan)
  • antipsychotics (e.g., clozapine, olanzapine, quetiapine, risperidone)
  • apixaban
  • barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
  • beta-blockers (e.g., atenolol, propranolol, timolol)
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • brimonidine
  • clopidogrel
  • conivaptan
  • dabigatran
  • digoxin
  • dipyridamole
  • diuretics (water pills; e.g., furosemide, hydrochlorothiazide, indapamide, spironolactone)
  • edoxaban
  • guanfacine
  • heparin
  • herbal products that affect blood clotting (e.g., cat’s claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, turmeric)
  • hydralazine
  • levodopa
  • low molecular weight heparins (e.g., dalteparin, enoxaparin, tinzaparin)
  • minoxidil
  • nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
  • nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., ibuprofen, ketorolac, naproxen)
  • obinutuzumab
  • pentoxifylline
  • phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
  • prasugrel
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
  • serotonin-norepinephrine reuptake inhibitors (SNRIs; desvenlafaxine, duloxetine, venlafaxine)
  • ticagrelor
  • ticlopidine
  • tolcapone
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996 – 2021. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: