Medication Search​ - Mycobutin

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How does Mycobutin work? What will it do for me?

Rifabutin belongs to the class of medications called antibacterials. It is used to prevent the spread of MAC (Mycobacterium avium complex) disease throughout the body in people with advanced HIV (human immunodeficiency virus) infection, or AIDS. People with this disease usually have fever, night sweats, chills, weight loss, and weakness.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does Mycobutin come in?

Each hard gelatin capsule with an opaque red-brown cap and body, imprinted with "PHARMACIA & UPJOHN/MYCOBUTIN" in white ink contains rifabutin 150 mg. Nonmedicinal ingredients: microcrystalline cellulose, magnesium stearate, red iron oxide, silica gel, sodium lauryl sulfate, titanium dioxide, and edible white ink.

How should I use Mycobutin?

The recommended adult dose of rifabutin is 300 mg once daily with or without food. Those who have nausea, vomiting, or stomach upset with this dose may take it as 150 mg twice daily with food.

The use and dose of rifabutin for children must be determined by the doctor on an individual basis.

 If this medication is not taken on a regular basis, side effects may occur more frequently and can be more severe than usual.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take Mycobutin?

Do not take this medication if you:

  • are allergic to rifabutin or any ingredients of this medication
  • are allergic to related medications (e.g., rifampin)

What side effects are possible with Mycobutin?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • burping
  • diarrhea (mild)
  • discolouration of spit, sweat, tears, or skin
  • indigestion
  • nausea
  • skin rash
  • stomach pain
  • urine discoloration
  • vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • joint or muscle pain
  • loss of strength or energy
  • symptoms of eye inflammation (eye pain, blurred vision, floating dark spots, redness, light sensitivity)
  • symptoms of an infection (such as fever or chills, sore throat, headache, overall weakness)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • chest pain
  • symptoms of antibiotic-associated diarrhea (severe, watery diarrhea that may be bloody)
  • symptoms of active tuberculosis (such as cough, fever, poor appetite, night sweats, and unintentional weight loss)
  • symptoms of a severe allergic reaction (such as hives, difficulty breathing, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for Mycobutin?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Antibiotic-associated diarrhea: This medication, like other antibiotics, may cause a potentially dangerous condition called antibiotic-associated, or pseudomembranous, colitis. Symptoms include severe, watery diarrhea that may be bloody. If you notice these symptoms, stop taking rifabutin and contact your doctor as soon as possible.

Blood counts: This medication can decrease the number of neutrophils (a type of white blood cell that helps fight infection), red blood cells (which carry oxygen), and platelets (which help your blood to clot). Your doctor will do blood tests to monitor this. If you notice any signs of infection (e.g., fever, chills, or sore throat) or unusual bleeding or bruising, contact your doctor immediately.

Body fluids: Urine may be coloured brown-orange while taking this medication. Your stools, saliva, sputum, perspiration, and tears may also be affected.

Contact lenses: The colouring of body fluids to a reddish-brown colour may cause soft contact lenses to permanently discolour. Hard contact lenses are not affected.

Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function:  Severe liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.

Tuberculosis: People with active tuberculosis should not use rifabutin. If you have this condition or suspect that you may have it (symptoms include cough, fever, poor appetite, night sweats, and unintentional weight loss), talk to your doctor.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if rifabutin passes into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication to prevent MAC infection have not been established for children under 18 years of age. Rifabutin has been used to treat MAC infection in children.

What other drugs could interact with Mycobutin?

There may be an interaction between rifabutin and any of the following:

  • anticancer medications (e.g., cabazitaxel, docetaxel; doxorubicin; etoposide, ifosfamide, irinotecan, vincristine)
  • certain antipsychotic medications (e.g., aripiprazole, clozapine, haloperidol, quetiapine)
  • atovaquone
  • "azole" antifungal medications (e.g., fluconazole, itraconazole, ketoconazole,)
  • BCG
  • barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
  • birth control pills
  • bosentan
  • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
  • carbamazepine
  • chloroquine
  • cholera vaccine
  • conivaptan
  • corticosteroids (e.g., dexamethasone, prednisone, hydrocortisone)
  • cyclosporine
  • dapsone
  • deferasirox
  • digoxin
  • disopyramide
  • elvitegravir
  • estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)
  • HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
  • HIV nucleoside reverse transcriptase inhibitors (NRTIs; e.g., abacavir, didanosine, lamivudine, tenofovir, zidovudine)
  • HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
  • isoniazid
  • kinase inhibitors (e.g., dabrafenib, dasatinib, imatinib, nilotinib)
  • macrolide antibiotics (e.g., clarithromycin, erythromycin)
  • methadone
  • modafinil
  • mycophenolate
  • narcotic pain relievers (e.g., fentanyl, morphine, oxycodone)
  • phenobarbital
  • phenytoin
  • primidone
  • primaquine
  • progestins (e.g., medroxyprogesterone acetate)
  • quinidine
  • quinine
  • raltegravir
  • rifampin
  • rilpivirine
  • romidepsin
  • St. John’s wort
  • selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
  • siltuximab
  • simeprevir
  • sirolimus
  • sodium picosulfate
  • sofosbuvir
  • "statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
  • sulfonylureas (e.g., gliclazide, glyburide, tolbutamide)
  • tacrolimus
  • tamoxifen
  • tocilizumab
  • tolterodine
  • tricyclic antidepressants (e.g., amitriptyline, imipramine, nortriptyline)
  • typhoid vaccine
  • warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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