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How does this medication work? What will it do for me?
Propafenone belongs to the class of medications known as antiarrhythmics. It is used to treat certain abnormal heart rhythms. It works by slowing down the rate of nerve impulses causing the heart to beat, and by making the heart less likely to respond to abnormal impulses.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
What form(s) does this medication come in?
Each white, round, biconvex, film-coated tablet, with "PF" over "150" on one side and "G" on the other, contains 150 mg of propafenone HCl. Nonmedicinal ingredients: sodium croscarmellose, microcrystalline cellulose, povidone, hydroxypropyl methylcellulose, colloidal anhydrous silica, sodium lauryl sulphate, and magnesium stearate; coating material: Opadry containing hypermellose, titanium dioxide, and macrogol or polyethylene glycol 400.
Each white, round, biconvex, film-coated tablet, with "PF" score line "300" on one side and a score line on the other, contains 300 mg of propafenone HCl. Nonmedicinal ingredients: sodium croscarmellose, microcrystalline cellulose, povidone, hydroxypropyl methylcellulose, colloidal anhydrous silica, sodium lauryl sulphate, and magnesium stearate; coating material: Opadry containing titanium dioxide, polydextrose, hypromellose, tracetin, and macrogol or polyethylene glycol 8,000.
How should I use this medication?
The recommended starting dose of propafenone for adults is 150 mg taken every 8 hours. This dose may be changed by your doctor according to your particular needs. The maximum daily dose is 900 mg per day.
Propafenone should be taken with food.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature and keep it out of the reach of children.
Who should NOT take this medication?
Do not take propafenone if you:
- are allergic to propafenone or any ingredients of the medication
- are taking the medication "ritonavir"
- have a very low heart rate (less than 50 beats per minute)
- have breathing disorders such as asthma
- have cardiogenic shock
- have certain types of heart rhythm disorders not managed with a pacemaker (i.e., sino-atrial, atrioventricular, and intraventricular disorders of impulse conduction and sinus node dysfunction)
- have had a heart attack in the last 3 months
- have myasthenia gravis
- have severe disorders of electrolytes (e.g., potassium) balance
- have severe liver failure
- have severe or uncontrolled congestive heart failure
- have very low blood pressure
What side effects are possible with this medication?
- bitter or metallic taste, or changes in taste
- blurred vision
- dry mouth
- increased sweating
- loss of appetite
- upset stomach
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- abnormal muscle control and movement
- fast, slow, or irregular heartbeat
- joint pain
- shaking or trembling
- signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
- signs of decreased heart function (e.g., shortness of breath, swelling of feet or lower legs, unusual tiredness or weakness)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- swelling of feet or lower legs
Stop taking the medication and seek immediate medical attention if any of the following occur:
- chest pain
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Abnormal heart rhythms: Certain medications used to treat abnormal heart rhythms, including propafenone, may cause new abnormal heart rhythms or worsen existing ones. Your doctor will monitor you closely while you are taking propafenone. If you experience a fast, slow, or irregular heartbeat; fainting; heart palpitations; or dizziness while taking this medication, contact your doctor immediately.
Asthma or bronchitis: Propafenone can worsen breathing problems for people with asthma or bronchitis. If you have asthma or other breathing disorders, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Drowsiness/reduced alertness: Propafenone may cause blurred vision, dizziness, and fatigue. Do not drive or operate machinery until you know how this medication affects you.
Heart failure: Propafenone can cause or worsen heart failure and should not be used by people with severe or untreated heart failure. If you have heart failure and are taking this medication, your doctor will monitor you closely during treatment. If you notice shortness of breath, weight gain, or swelling in the hands, feet, or lower legs while taking propafenone, contact your doctor immediately.
If you have a heart condition, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Infection: Propafenone can reduce the number of cells that fight infection in the body (white blood cells). This usually occurs within 4 to 6 weeks of starting this medication. If you experience fever, sore throat, fatigue, weakness, or a general feeling of being unwell while taking propafenone, contact your doctor immediately.
Kidney function: Kidney disease or reduced kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Liver function: The liver removes most of this medication from the body. Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking this medication.
If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Pregnancy: This medication should not be taken during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking propafenone, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.
Seniors: Seniors may experience more dizziness while taking propafenone and may require lower doses.
What other drugs could interact with this medication?
There may be an interaction between propafenone and any of the following:
- antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- "azole" antifungals (e.g., ketoconazole, fluconazole, voriconazole)
- barbiturates (e.g., butalbital, pentobarbital, phenobarbital)
- beta-adrenergic blockers (e.g., metoprolol, propranolol)
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- chloral hydrate
- grapefruit juice
- HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
- HIV protease inhibitors (e.g., lopinavir, ritonavir, saquinavir, tipranavir)
- macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
- peginterferon alfa-2b
- quinolone antibiotics (e.g., ciprofloxacin, levofloxacin, norfloxacin)
- selective serotonine reuptake inhibitors (SSRIs; escitalopram, fluoxetine, paroxetine)
- serotonin antagonists (anti-emetic medications; e.g., granisetron, ondansetron)
- theophylline medications (e.g., aminophylline, oxtriphylline, theophylline)
- tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine)
- tyrosine kinase inhibitors (e.g., dasatinib, imatinib, nilotinib, sunitinib)
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
All material copyright MediResource Inc. 1996 – 2021. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Mylan-Propafenone