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How does this medication work? What will it do for me?
Trimipramine belongs to a class of medications called tricyclic antidepressants (TCAs). It is used to treat depression and works by affecting the balance of certain chemicals called neurotransmitters in the brain.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
What form(s) does this medication come in?
How should I use this medication?
The recommended starting dose of trimipramine is 75 mg daily in 2 or 3 divided doses. Your doctor may increase the dose gradually until a response to the medication occurs (this may take a few weeks or more). The dose is then adjusted to control the symptoms with acceptable side effects. The usual maintenance dose is approximately 150 mg to 200 mg daily in divided doses.
Trimipramine may be taken with or without food.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important that this medication be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Who should NOT take this medication?
Trimipramine should not be taken by anyone who:
- is allergic to any of the ingredients of the medication
- is allergic to other dibenzazepine-type medications
- is also taking a MAO inhibitor (e.g., phenelzine, tranylcypromine) or has taken one within the last 2 weeks
- has acute congestive heart failure
- has just had a heart attack
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
- dryness of mouth
- increased appetite (may include a craving for sweets)
- increased sweating
- tiredness or weakness (mild)
- trouble sleeping
- unpleasant taste
- weight gain
Check with your doctor as soon as possible if any of the following side effects occur:
- breast enlargement (both males and females)
- hair loss
- inappropriate secretion of milk (females)
- increased sensitivity to sunlight
- muscle twitching
- red or brownish spots on skin
- ringing, buzzing, or other unexplained sounds in the ears
- skin rash and itching
- sore throat and fever
- swelling of face and tongue
- swelling of testicles
- trouble with teeth or gums
- yellow eyes or skin
Are there any other precautions or warnings for this medication?
Alcohol: Your response to alcoholic beverages may be affected while taking this medication.
Constipation: Trimipramine may cause constipation, especially for seniors.
Medical conditions: Trimipramine should be used with caution by people with a history of seizures, urinary retention, glaucoma, or thyroid disease. Tricyclic antidepressant medications such as trimipramine, particularly when taken in high doses, can cause abnormal heart rhythms. Therefore, trimipramine should be taken with caution by seniors or people with a history of heart disease.
Mental and physical impairment: Trimipramine may impair the mental or physical abilities required for the performance of potentially hazardous tasks, such as driving or operating machinery.
Withdrawal: Stopping treatment with trimipramine after having taken it for a long period of time may produce nausea, headache, and malaise. These symptoms do not mean that you are addicted to the medication. Do not stop taking trimipramine suddenly without first talking with your doctor.
Pregnancy: The safety of trimipramine for use during pregnancy has not been established. If you are or may be pregnant, the possible benefits of taking this medication must be weighed against the possible risks. If you are or may be pregnant, talk to your doctor.
Breast-feeding: The safety of trimipramine for use while breast-feeding has not been established. If you are breast-feeding, the possible benefits of taking this medication must be weighed against the possible risks to the child. If you are breast-feeding, talk to your doctor.
What other drugs could interact with this medication?
There may be an interaction between trimipramine and any of the following:
- amphetamines (e.g., dextroamphetamine)
- anticholinergic medications (e.g., benztropine, atropine)
- appetite suppressants (e.g., mazindol, phentermine)
- barbiturates (e.g., phenobarbital, secobarbital)
- benzodiazepines (e.g., diazepam, lorazepam)
- divalproex sodium
- MAO inhibitors (e.g., tranylcypromine, phenelzine)
- sympathomimetic medications (e.g., dopamine, epinephrine)
- valproic acid
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2021. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Nu-Trimipramine