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How does this medication work? What will it do for me?
Ropinirole belongs to the class of medications called antiparkinsonian agents. It is used to treat the signs and symptoms of Parkinson’s disease. It helps to improve muscle control and movement by affecting the balance of a chemical in the brain called dopamine.
Ropinirole may be used alone or in combination with another medication called levodopa, which is also used to treat Parkinson’s disease. It may take several weeks for ropinirole to take effect.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each white-to-off-white, film-coated, pentagonal, centrally tipped tablet debossed with "R" on one side and "6" on the other contains 0.25 mg of ropinirole hydrochloride. Nonmedicinal ingredients: cellulose microcrystalline, croscarmellose sodium, hypromellose, lactose anhydrous, lactose monohydrate, magnesium stearate, macrogol/polyethylene glycol 400, titanium dioxide, and talc.
Each light-green-to-green, film-coated, pentagonal, centrally tipped tablet debossed with "R" on one side and "8" on the other contains 1 mg of ropinirole hydrochloride. Nonmedicinal ingredients: cellulose microcrystalline, croscarmellose sodium, FD&C Blue No. 2/lake colour of indigo carmine, hypromellose, iron oxide black lactose anhydrous, iron oxide yellow, lactose monohydrate, magnesium stearate, macrogol/polyethylene glycol 400, and titanium dioxide.
Each pink, film-coated, pentagonal, centrally tipped tablet debossed with "R" on one side and "9" on the other contains 2 mg of ropinirole hydrochloride. Nonmedicinal ingredients: cellulose microcrystalline, croscarmellose sodium, hypromellose, iron oxide red, lactose anhydrous, lactose monohydrate, magnesium stearate, macrogol/polyethylene glycol 400, and titanium dioxide.
Each blue, film-coated, pentagonal, centrally tipped tablet debossed with "R" on one side and "11" on the other contains 5 mg of ropinirole hydrochloride. Nonmedicinal ingredients: cellulose microcrystalline, croscarmellose sodium, FD&C Blue No. 2/lake colour of indigo carmine, hypromellose, lactose anhydrous, lactose monohydrate, macrogol/polyethylene glycol 400, macrogol/polyethylene glycol 4000, magnesium stearate, talc, and titanium dioxide.
How should I use this medication?
The recommended adult starting dose of ropinirole is 0.25 mg taken 3 times daily. The dose may be increased weekly up to a maximum of 8 mg taken 3 times daily as needed in individual circumstances.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor.
Ropinirole may be taken with or without food. If nausea occurs, take the tablets with food to prevent stomach upset. The tablets should be swallowed whole and not chewed.
This medication should not be stopped suddenly. If you feel it is necessary to stop taking ropinirole, discuss the best way to do so with your doctor.
It is important to take this medication exactly as prescribed by the doctor. If you miss a dose of this medication, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not take ropinirole if you are allergic to ropinirole or any ingredients of the medication.
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- decrease in sexual desire or performance
- stomach ache
- unusual tiredness or weakness
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- extreme sleepiness
- falling asleep without warning
- hallucinations (seeing, hearing, or feeling things that are not there)
- impulse control (e.g., increased sex drive, gambling, urge to shop or eat, aggressive behaviour)
- lightheadedness or fainting, especially when standing up
- personality changes (e.g., paranoia, agitation, anxiety, nervousness)
- swelling of legs
- trouble swallowing
- twisting, twitching, or other unusual body movements
- uncontrollable movements
- viral infections
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, swelling of the face and throat)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
Behaviour and personality changes: Ropinirole can cause behaviour changes including hallucinations, pathological gambling, and increased libido. Personality changes may also occur, including paranoia, anxiety or nervousness, or a sense of not being oneself.
If you experience changes in behaviour or are aware of these changes happening in someone who is taking ropinirole, contact the doctor as soon as possible.
Breathing problems: Ropinirole has been known to cause scarring or thickening of the tissues in the abdomen, including the lungs and heart. If you experience any difficulty breathing or chest pain, contact your doctor as soon as possible.
Dizziness: Ropinirole may cause dizziness when getting up from a lying or sitting position to a standing position. This usually happens at the start of treatment or when the dose is being increased. You can decrease the frequency of this happening by rising slowly when you sit up or stand up.
Hallucinations: Ropinirole causes hallucinations for about 5% of people who take it and for about 10% of people who take it at the same time as levodopa. The incidence of hallucinations increases as the dose increases. If you experience hallucinations or are aware of a person who is taking ropinirole experiencing hallucinations, contact the doctor as soon as possible.
Heart disease: This medication has not been studied for use by people with significant heart disease. If you have heart disease and are taking ropinirole, discuss with your doctor how this medication may affect your medical condition, and how your medical condition may affect the dosing and effectiveness of this medication. Your doctor will want to monitor your heart condition closely while you are taking ropinirole.
Kidney function: If you have reduced kidney function or kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed
Liver function: The safety and effectiveness of ropinirole when used by people with reduced liver function has not been studied. Ropinirole is not recommended for people with reduced liver function.
Melanoma: People with Parkinson’s disease may be at increased risk of developing melanoma (a type of skin cancer). It is not known if this increased risk is due to Parkinson’s disease or to the medications used to treat Parkinson’s disease. Your doctor will monitor you for skin cancer while you are taking this medication. Talk to your doctor if you have any concerns.
Neuroleptic malignant syndrome (NMS): As with other medications that have an effect on movement disorders, ropinirole can trigger a potentially fatal set of symptoms known as neuroleptic malignant syndrome (NMS). If you experience symptoms of NMS, such as high fever, muscle stiffness, confusion or loss of consciousness, sweating, rapid or irregular heartbeat, seek immediate medical attention.
This is more likely to occur if ropinirole is stopped suddenly or the dose is decreased rapidly. If you are considering stopping this medication, discuss the appropriate way to reduce ropinirole with your doctor.
Sudden onset of sleep: Ropinirole can cause the sudden, unpredictable onset of sleep. This can happen while participating in the daily activities of living, including driving or operating machinery. This effect may occur at any point while taking the medication.
Because there is no warning when or if this will occur, do not drive or operate dangerous machinery while you are taking ropinirole.
Uncontrolled movements: Ropinirole may cause an increase in irregular, jerky movements or uncontrolled body movements when it is taken with levodopa. If you notice movement problems worsening, contact your doctor as soon as possible.
Pregnancy: The use of ropinirole during pregnancy is not recommended. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: Ropinirole reduces the production of breast milk, and therefore, should not be taken by women who wish to breast-feed.
Children: The safety and effectiveness of this medication have not been established for use by children.
What other drugs could interact with this medication?
There may be an interaction between ropinirole and any of the following:
- alpha-agonists (e.g., clonidine, methyldopa)
- alpha-blockers (e.g., alfuzosin, doxazosin, tamsulosin)
- angiotensin converting enzyme inhibitors (ACEIs; captopril, ramipril)
- angiotensin receptor blockers (ARBs; e.g., candesartan, irbesartan, losartan)
- antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
- barbiturates (e.g., butalbital, pentobarbital phenobarbital)
- benzodiazepines (e.g., alprazolam, diazepam, lorazepam)
- beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- chloral hydrate
- diuretics (water pills; e.g., furosemide, hydrochlorothiazide, triamterene)
- estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)
- general anesthetics (medications used to put people to sleep before surgery)
- iron sucrose
- monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)
- muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine, tizanidine)
- narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)
- nitrates (e.g., nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)
- phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
- seizure medications (e.g., clobazam, ethosuximide, felbamate, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)
- tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2021. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/RAN-Ropinirole