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ombitasvir - paritaprevir - ritonavir
How does this medication work? What will it do for me?
This medication is a combination of the medications ombitasvir, paritaprevir, and ritonavir in one tablet. Together, these medications belong to the class of medications called antivirals. This medication is used with ribavirin to treat chronic hepatitis C (CHC) infection caused specifically by the genotype 4 variant of hepatitis C virus.
Ombitasvir and paritaprevir work in different ways to reduce the reproduction of the hepatitis C virus. Ritonavir contributes to this effect by increasing the amount of paritaprevir available to be used by the body with each dose.
This medication does not prevent the spread of hepatitis C through sexual contact or blood contamination and it does not prevent you from being reinfected with the hepatitis C virus.
If you are taking this medication with ribavirin, please refer to the information article for ribavirin, in addition to this article.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What form(s) does this medication come in?
Each pink, film-coated, oblong, biconvex-shaped tablet debossed “AV1” on one side, contains 12.5 mg ombitasvir, 75 mg paritaprevir and 50 mg ritonavir. Nonmedicinal ingredients: colloidal silicon dioxide/anhydrous colloidal silica, copovidone, propylene glycol monolaurate, sodium stearyl fumarate, sorbitan monolaurate, and vitamin E polyethylene glycol succinate; film-coating: iron oxide red, polyethylene glycol/macrogol, polyvinyl alcohol, purified water, talc, and titanium dioxide. The tablets do not contain gluten.
How should I use this medication?
The recommended dose of ombitasvir – paritaprevir – ritonavir is 2 tablets taken once daily in the morning with food. This medication must be taken in combination with ribavirin.
Swallow the tablets whole with water. They should not be chewed, broken, or crushed.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, and it is less than 12 hours since the missed dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Who should NOT take this medication?
Do not take this medication if you:
- are allergic to ombitasvir, paritaprevir, ritonavir, or any ingredients of the medication
- are or may be pregnant
- have severely decreased liver function
- have experienced a severe hypersensitivity reaction to ritonavir (toxic epidermal necrolysis or Steven-Johnson syndrome)
- are taking any of the following medications:
- ergot derivatives (e.g., ergotamine, dihydroergotamine)
- ethinyl estradiol
- midazolam taken by mouth
- St. John’s wort
- sildenafil (when used for pulmonary hypertension)
What side effects are possible with this medication?
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- loss of appetite
- stomach ache
- trouble sleeping
- unusual weakness
Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
Stop taking the medication and seek immediate medical attention if any of the following occur:
- signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
- signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.
Are there any other precautions or warnings for this medication?
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
HEALTH CANADA ADVISORY
December 1, 2016
Health Canada has issued new restrictions concerning the use of Technivie® (ombitasvir – paritaprevir – ritonavir). To read the full Health Canada Advisory, visit Health Canada’s web site at www.hc-sc.gc.ca.
A previous advisory on ombitasvir – paritaprevir – ritonavir was issued on November 10, 2015.
To read the full Health Canada Advisory, visit Health Canada’s web site at www.hc-sc.gc.ca.
Hepatitis B co-infection: The safety and effectiveness of using this medication have not been established for people who also have hepatitis B infection. If you have hepatitis B infection, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Human immunodeficiency virus (HIV) co-infection: The safety and effectiveness of using this medication have not been established for people who also have HIV infection. If you have HIV infection, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Because ritonavir is also used to treat HIV infection, this medication could contribute to ritonavir being less effect in your HIV treatment, if the virus becomes resistant to ritonavir.
Liver function: This medication has not been studied for safety and effectiveness when used by people with moderately reduced liver function. If you have reduced liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. People with severely reduced liver function should not use this medication.
This medication has been reported to cause signs of decreased liver function. This most commonly appears with women who are taking other medications that contain ethinyl estradiol, such as some birth control pills, however it may be experienced by anyone taking ombitasvir – paritaprevir – ritonavir. Medications containing ethinyl estradiol should be stopped before starting to take ombitasvir – paritaprevir – ritonavir.
If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.
Breast-feeding: It is not known if ombitasvir, ritonavir, or paritaprevir pass into breast milk. If you are a breast-feeding mother and are taking this medication, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using this medication have not been established for children.
What other drugs could interact with this medication?
There may be an interaction between ombitasvir – paritaprevir – ritonavir and any of the following:
- abiraterone acetate
- alpha blockers (e.g., alfuzosin, doxazosin, silodosin, tamsulosin)
- anti-cancer medications (e.g., cabazitaxel, docetaxel; doxorubicin; etoposide, ifosfamide, irinotecan, vincristine)
- antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzepine, quetiapine, risperidone)
- "azole" antifungals (e.g., itraconazole, ketoconazole, voriconazole)
- benzodiazepines (e.g., chlordiazepoxide, clonazepam, diazepam, lorazepam, midazolam, triazolam)
- calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
- estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)
- ergot alkaloids (e.g., dihydroergotamine, ergonovine, ergotamine, methylergonovine)
- "gliptin" diabetes medications (e.g., linagliptin, saxagliptin, sitagliptin)
- grapefruit juice
- HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delaviridine, efavirenz, etravirine, nevirapine)
- HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
- inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
- macrolide antibiotics (e.g., clarithromycin, erythromycin)
- narcotic pain relievers (e.g., fentanyl, hydrocodone, methadone, oxycodone)
- nitrates (e.g., isosorbide dinitrate, isosorbide mononitrate, nitroglycerine)
- oral corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)
- other hepatitis C antiviral medications (e.g., boceprevir, ledipasvir, sofosbuvir, telaprevir)
- phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
- progestins (e.g., dienogest, levonorgestrel, medroxyprogesterone, norethindrone)
- protein kinase inhibitors (e.g., bosutinib, dasatinib, imatinib)
- proton pump inhibitors (e.g., lansoprazole, omeprazole)
- St. John’s wort
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)
- "statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
- tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine)
If you are taking any of these medications, speak with your doctor or pharmacist.
Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 – 2021. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Technivie