Medication Search​ - Yervoy

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How does Yervoy work? What will it do for me?

Ipilimumab belongs to the group of cancer-fighting medications known as antineoplastics, more specifically it is a monoclonal antibody. It works by stimulating the body’s immune system to attack the cancer cells, reducing the size of the tumours.

This medication is used alone or with other medications to treat melanoma, a specific type of skin cancer, that has spread (metastasized) or cannot be removed by surgery.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does Yervoy come in?

Each 1 mL of solution for infusion contains 5 mg of ipilimumab. Nonmedicinal ingredients: tris hydrochloride, sodium chloride, mannitol, diethylene triamine pantaacetic acid (DTPS), polysorbate 80, water for injection, and sodium hydroxide or hydrochloric acid to adjust pH.

How should I use Yervoy?

The recommended starting dose for adults is based on weight. The initial dose is 3 mg per kilogram of body weight.

This medication is given by intravenous (into a vein) infusion over 90 minutes once every 3 weeks for a total of 4 doses. It is usually injected through a site on your skin specially prepared for this purpose.

Very careful handling of this medication is required. Ipilimumab should only be given by health care professionals familiar with the use of chemotherapy medications used to treat cancer. It is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.

It is important this medication be given exactly as recommended by your doctor. If you miss an appointment to receive ipilimumab, contact your doctor as soon as possible to reschedule your appointment.

This medication will be stored at the hospital or clinic in the refrigerator and protected from light.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take Yervoy?

Do not take this medication if you:

  • are allergic to ipilimumab or any ingredients of the medication
  • have a life-threatening autoimmune disease
  • have had an organ transplant

What side effects are possible with Yervoy?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

  • diarrhea
  • fatigue
  • feeling tired or weak
  • itching
  • loss of appetite
  • nausea
  • stomach pain
  • vomiting

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

  • behavior changes (irritability, forgetfulness)
  • decreased interest in sexual activity
  • difficulty hearing
  • dizziness
  • eye pain or redness
  • fainting
  • headaches
  • neck stiffness
  • numbness or tingling in the hands or feet
  • ringing in the ears
  • signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
  • symptoms of intestinal inflammation (e.g., diarrhea, blood in stools, stomach pain or tenderness)
  • symptoms of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • symptoms of skin inflammation (e.g., skin rash, mouth blisters, peeling skin)
  • unusual tiredness or sleepiness
  • weakness in the arms, legs, or face
  • vision changes (blurred or double vision)

Stop taking the medication and seek immediate medical attention if any of the following occur:

  • paralysis
  • signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
  • signs of an infusion reaction (e.g., flushing, chest pain, difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for Yervoy?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Autoimmune illnesses: If you have an autoimmune disease, such as lupus, using ipilimumab may make the condition worse by stimulating your immune system. This medication is not intended for use by people with autoimmune disorders.

Drowsiness/reduced alertness: Ipilimumab may cause tiredness or fatigue, affecting your ability to drive or operate machinery. Avoid these and other hazardous tasks until you have determined how this medication affects you.

Immune system reactions: Ipilimumab can cause inflammation to many parts of the body, including the stomach, liver, skin, nerves, hormone glands (e.g. pituitary, adrenal, thyroid), and eyes. This may occur during treatment and up to several months after your last infusion. It is important that you contact your doctor about any concerning side effects.

Immunosuppressant medications: Ipilimumab works by stimulating the immune system. If you have had an organ transplant, ipilimumab may cause your body to reject the organ. This medication is not intended for use by people who are taking immunosuppressants.

Infusion reactions: This medication can cause a hypersensitivity or infusion reaction. Symptoms of this type of reaction generally appear during the infusion of the medication and may include flushing, chest pain, shortness of breath, and a dramatic drop in blood pressure. These reactions can cause death if a health care provider is not informed immediately. If you experience any of these symptoms, or notice them happening to someone, let your nurse or doctor know immediately.

Liver function: Ipilimumab may cause liver damage or reduced liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Medication-related diarrhea: Ipilimumab can cause inflammation to many parts of the body, including the digestive system. This condition, known as enterocolitis, can become life threatening if it is not treated quickly. If you experience diarrhea with mucus or blood in the stool, contact your doctor as soon as possible.

Pregnancy: Ipilimumab may cause harm to a developing baby if the mother uses this medication during pregnancy. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking ipilimumab, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using this medication have not been established for children.

What other drugs could interact with Yervoy?

There may be an interaction between ipilimumab and any of the following:

  • medications that suppress the immune system (e.g., cancer medications, corticosteroids, mycophenolate, tacrolimus, cyclosporine)
  • vemurafenib

If you are taking any of these medications, speak with your doctor or pharmacist.

Depending on your specific circumstances, your doctor may want you to:

  • stop taking one of the medications,
  • change one of the medications to another,
  • change how you are taking one or both of the medications, or
  • leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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